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Human growth hormone (HGH) is a heterogenous­ mixture of polypeptides­ secreted by the anterior pituitary gland. The principal form of HGH is a polypeptide containing 191 amino acids with a molecular weight of 215,000 daltons. This form of HGH is produced by recombinant DNA technology and is marketed for the treatment of short stature in growth hormone(GH)-defi­cient children and adolescents.­ Recombinant HGH or somatropin is also used for the treatment of GH deficiency in adults, short stature in association with renal insufficiency,­ AIDS-related­ wasting and short stature associated with Turner's Syndrome. In all of these cases, GH must be administered­ parenterally­ since it has very poor oral bioavailability.­

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